Changes in your blood tests do not indicate anything specific about your wife's hepatitis B status. She needs to have her own blood tests to see what is happening with her disease. There are treatments for hepatitis B now, so I suggest she get followed up in any case. Your rising levels could be related to the booster shot. I know you are thinking perhaps they are rising in response to contact with her virus. Certainly this is a possibility, but again, it's best that she get checked periodically anyway and consider treatment for her carrier state. Hope this helps.